AT4 receptor binding in the developing rabbit

被引：1

作者：

Burns, GA ^{[1
]}

Thiessen, AM ^{[1
]}

Hanesworth, J ^{[1
]}

Harding, JW ^{[1
]}

机构：

[1] Washington State Univ, Coll Vet Med, Dept Vet Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA

来源：

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2004年 / 281A卷 / 02期

关键词：

angiotensin IV; fetal; organogenesis; Divalinal-AngIV; autoradiography;

D O I：

10.1002/ar.a.20070

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The binding of the AT(4)-specific analog, divalinal-AngIV (Dival), was studied in rabbit fetuses of various gestational ages. Saturation isotherm and competition data from selected tissues indicate that fetal Dival binding sites are saturable and specific for AT(4) ligands. Autoradiographs revealed that binding was present in all the specimens examined. The peripheral nerves, kidneys, and heart were particularly heavily labeled. Labeling of some tissues, such as forming bones, was not constant as gestational age increased. Other tissues, including multilocular fat, sinus hairs, and enamel organs of nascent teeth, exhibited substantial binding as these tissues developed. (C) 2004 Wiley-Liss, Inc.

引用

页码：1276 / 1285

页数：10

共 40 条

[1] Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase [J].