A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

被引：41

作者：

Morris, LA

Christie, EM

Jaspars, M ^{[1
]}

van Ofwegen, LP

机构：

[1] Univ Aberdeen, Dept Chem, Marine Nat Prod Lab, Old Aberdeen AB24 3UE, Scotland

[2] Museum Natl Hist Nat, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 04期

关键词：

D O I：

10.1021/np9705118

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.

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页码：538 / 541

页数：4

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