Differential effects of selective adenosine A1 and A2A receptor agonists on dopamine receptor agonist-induced behavioural responses in rats

被引:74
作者
Rimondini, R [1 ]
Ferré, S [1 ]
Giménez-Llort, L [1 ]
Ögren, SO [1 ]
Fuxe, K [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, Div Cellular & Mol Neurochem, S-17177 Stockholm, Sweden
关键词
dopamine D-1 receptor; dopamine D-2 receptor; adenosine A(1) receptor; adenosine A(2A) receptor; stereotypy; yawning; grooming;
D O I
10.1016/S0014-2999(98)00107-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of the systemic (i.p.) administration of the selective adenosine A(1) receptor agonist N-6-cyclopentyladenosine (CPA) and the selective adenosine A(2A) receptor agonist sodium 2-p-carboxyethyl)phenylamino-5'-N-carboxamidoadenosine (CGS 21680) on different dopamine receptor agonist-induced behaviours were studied in the male rat. CGS 21680 (1 mu mol/kg), but not CPA, was found to counteract the stereotypies induced by the non-selective dopamine receptor agonist apomorphine (0.25 mg/kg s.c.). Low doses of CGS 21680 (0.1 mu mol/kg) and high doses of CPA (3 mu mol/kg) counteracted yawning induced by the dopamine D-2 selective agonist quinpirole (0.05 mg/kg). On the other hand, low doses of CPA (0.3 mu mol/kg) antagonized grooming induced by the selective dopamine D-1 receptor-selective agonist SKF 38393 (10 mg/kg i.p.), while CGS 21680 was ineffective. These results are consistent with the proposed existence of a selective antagonistic modulation of dopamine D-1 and D-2 receptors by adenosine A(1) and A(2A) receptors, respectively. The ability of CGS 21680 to counteract apomorphine-induced stereotypies is weaker compared to its previously reported antagonistic effect of amphetamine-induced motor activity. This supports the hypothesis that adenosine A(2A) receptor agonists may be potential antipsychotic drugs with a low potential for extrapyramidal side effects. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:153 / 158
页数:6
相关论文
共 24 条
[1]  
ALTAR CA, 1986, BRAIN RES BULL, V16, P517
[2]   DOPAMINE D-1 RECEPTOR AGONISTS COMBINED WITH THE SELECTIVE D-2 AGONIST QUINPIROLE FACILITATE THE EXPRESSION OF ORAL STEREOTYPED BEHAVIOR IN RATS [J].
ARNT, J ;
HYTTEL, J ;
PERREGAARD, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 133 (02) :137-145
[3]  
BORISON RL, 1983, CLIN NEUROPHARMAC, V76, P137
[4]   Adenosine-dopamine interactions in the ventral striatum - Implications for the treatment of schizophrenia [J].
Ferre, S .
PSYCHOPHARMACOLOGY, 1997, 133 (02) :107-120
[5]   POSTSYNAPTIC ANTAGONISTIC INTERACTION BETWEEN ADENOSINE A(1) AND DOPAMINE D-1 RECEPTORS [J].
FERRE, S ;
POPOLI, P ;
GIMENEZLLORT, L ;
FINNMAN, UB ;
MARTINEZ, E ;
DECAROLIS, AS ;
FUXE, K .
NEUROREPORT, 1994, 6 (01) :73-76
[6]   ADENOSINE DOPAMINE INTERACTIONS IN THE BRAIN [J].
FERRE, S ;
FUXE, K ;
VONEULER, G ;
JOHANSSON, B ;
FREDHOLM, BB .
NEUROSCIENCE, 1992, 51 (03) :501-512
[7]   Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia [J].
Ferre, S ;
Fredholm, BB ;
Morelli, M ;
Popoli, P ;
Fuxe, K .
TRENDS IN NEUROSCIENCES, 1997, 20 (10) :482-487
[8]  
FUXE K, 1977, RHINENCEPHALE NEUROT, P253
[9]   CATALEPSY AS A RODENT MODEL FOR DETECTING ANTIPSYCHOTIC-DRUGS WITH EXTRAPYRAMIDAL SIDE-EFFECT LIABILITY [J].
HOFFMAN, DC ;
DONOVAN, H .
PSYCHOPHARMACOLOGY, 1995, 120 (02) :128-133
[10]   PERMISSIVE ROLE OF D-1 RECEPTOR STIMULATION BY ENDOGENOUS DOPAMINE FOR THE EXPRESSION OF POSTSYNAPTIC D-2-MEDIATED BEHAVIORAL-RESPONSES - YAWNING IN RATS [J].
LONGONI, R ;
SPINA, L ;
DICHIARA, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 134 (02) :163-173