Cyclooxygenases and the central nervous system

被引：227

作者：

Kaufmann, WE

Andreasson, KL

Isakson, PC

Worley, PF

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21205 USA

[4] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT, BALTIMORE, MD 21205 USA

[5] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA

[6] SEARLE RES & DEV, ST LOUIS, MO USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1997年 / 54卷 / 03期

关键词：

cyclooxygenase; central nervous system;

D O I：

10.1016/S0090-6980(97)00128-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandins (PGs) were first described in the brain by Samuelsson over 30 years ago (Samuelsson, 1964). Since then a large number of studies have shown that PGs are formed in regions of the brain and spinal cord in response to a variety of stimuli. The recent identification of two forms of cyclooxygenase (COX; Kujubu et al., 1991; Xie et al., 1991; Smith and DeWitt, 1996), both of which are expressed in the brain, along with superior tools for mapping COX distribution has spurred a resurgence of interest in the role of PGs in the central nervous system (CNS). In this review we will describe new data in this area, focusing on the distribution and potential role of the COX iso-forms in brain function and disease.

引用

页码：601 / 624

页数：24

共 177 条

[1] PROSTAGLANDIN PROFILES IN NERVOUS-TISSUE AND BLOOD-VESSELS OF THE BRAIN OF VARIOUS ANIMALS [J].