The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

被引：42

作者：

Harris, James ^{[1
]}

Sharp, Fiona A. ^{[1
]}

Lavelle, Ed C. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Adjuvant Res Grp, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期

基金：

爱尔兰科学基金会;

关键词：

Adjuvant; Inflammasome; Interleukin; 1; Vaccine; ALUMINUM-CONTAINING ADJUVANTS; INFLAMMATORY DENDRITIC CELLS; NLRP3; INFLAMMASOME; NALP3; HOST-DEFENSE; MYCOBACTERIUM-TUBERCULOSIS; ADAPTIVE IMMUNITY; CANDIDA-ALBICANS; CUTTING EDGE; CRUCIAL ROLE;

D O I：

10.1002/eji.200940172

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.

引用

页码：634 / 638

页数：5

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