Cyclooxygenase induction is essential for NGF synthesis enhancement by NGF inducers in L-M cells

被引：11

作者：

Yamaguchi, K

Tsuji, Y

Uemura, D

Kondo, K

机构：

[1] Sagami Chemical Research Center, Kanagawa, 229, Nishiolmuma 4-4-1, Sagamihara

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 01期

关键词：

nerve growth factor; nerve growth factor inducers; cyclooxygenase; prostaglandin;

D O I：

10.1271/bbb.60.92

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nerve growth factor (NGF) inducers, for example, 4-methylcatechol, pyrroloquinoline quinone, kansuinin A, and ingenol triacetate, stimulate NGF synthesis in L-M cells, but the mechanism of NGF induction by NGF inducers is not known. Using the four different types of previously described NGF inducers, we proved induction of cyclooxygenase activity by NGF inducers and detected prostaglandins D-2 and E(2) as metabolites of arachidonic acid. From the observation that the induction of NGF by each NGF inducers was inhibited by cyclooxygenase inhibitors or dexamethasone, cyclooxygenase activation is supposed to be an essential process for NGF induction.

引用

页码：92 / 94

页数：3

共 32 条

[1]

BAILEY JM, 1991, BIOFACTORS, V3, P97

[2] NEONATAL BRAIN-DAMAGE AND RECOVERY - INTRAVENTRICULAR-INJECTION OF NGF AT TIME OF INJURY ALTERS PERFORMANCE OF ACTIVE-AVOIDANCE [J].