KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases

被引：31

作者：

Fukaya, S ^{[1
]}

Oshima, H ^{[1
]}

Kato, K ^{[1
]}

Komatsu, Y ^{[1
]}

Matsumura, H ^{[1
]}

Ishii, K ^{[1
]}

Miyama, H ^{[1
]}

Nagai, T ^{[1
]}

Tanaka, I ^{[1
]}

Mizutani, A ^{[1
]}

Katayama, M ^{[1
]}

Yoshida, S ^{[1
]}

Torikai, K ^{[1
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Med, Toyoake, Aichi 4701192, Japan

来源：

RHEUMATOLOGY INTERNATIONAL | 2000年 / 19卷 / 06期

关键词：

interstitial pneumonia; KL-6; corticosteroids; marker;

D O I：

10.1007/s002960000064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.

引用

页码：223 / 225

页数：3

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