Water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats

被引：54

作者：

Lee, YM

Kim, H

Hong, EK

Kang, BH

Kim, SJ

机构：

[1] Kyung Hee Univ, Dept Pharmacol, Sch Dent, Seoul, South Korea

[2] Kyung Hee Univ, E W Pharmaceut Res Inst, Seoul, South Korea

[3] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 151742, South Korea

[4] Taelim Pharmaceut Co, Seoul, South Korea

[5] Korea Res Inst Chem Technol, Toxicol Res Ctr, Seoul, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 73卷 / 03期

关键词：

Phellodendron cortex; Aralia cortex; anti-oxidant; diabetic kidney complication;

D O I：

10.1016/S0378-8741(00)00302-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Enhanced activity of the lipid peroxidation and oxidative damages have been implicated in the pathogenesis of diabetic kidney complications. We explored to determine whether these changes in diabetic kidney could be prevented by water extract of mixture of Phellodendron cortex and Aralia cortex (P55A). Greatly elevated content of thiobarbituric acid reactive substances (TBARS) and carbonylated protein in kidneys of diabetic rats were significantly reduced by P55A treatment. In addition, abnormally low ratio of GSH/GSSG in diabetic kidneys was elevated to almost normal levels by the treatment with P55A. These results suggest that P55A extracts exert antioxidant effect by reducing lipid peroxidation and protein carbonylation as well as by elevating the ratio of GSF/GSSG in diabetic kidney. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：429 / 436

页数：8

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