Host responses to Candida albicans: Th17 cells and mucosal candidiasis

被引:113
作者
Conti, Heather R. [2 ]
Gaffen, Sarah L. [1 ,2 ]
机构
[1] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15261 USA
[2] SUNY Buffalo, Dept Oral Biol, Buffalo, NY 14260 USA
关键词
Th17; IL-17; Candida albicans; CHRONIC MUCOCUTANEOUS CANDIDIASIS; HUMAN-IMMUNODEFICIENCY-VIRUS; IL-17; RECEPTOR; PATTERN-RECOGNITION; NLRP3; INFLAMMASOME; OROPHARYNGEAL CANDIDIASIS; PROTECTIVE IMMUNITY; HUMAN DECTIN-1; ANIMAL-MODELS; T-CELLS;
D O I
10.1016/j.micinf.2010.03.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immuno-compromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:518 / 527
页数:10
相关论文
共 89 条
[1]   Defects along the TH17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome [J].
Al Khatib, Shadi ;
Keles, Sevgi ;
Garcia-Lioret, Maria ;
Koc-Aydiner, Elif Kara ;
Reisli, Ismail ;
Artac, Hasibe ;
Camcioglu, Yildiz ;
Cokugras, Haluk ;
Somer, Ayper ;
Kutukculer, Necil ;
Yilmaz, Mustafa ;
Ikinciogullari, Aydan ;
Yegin, Olcay ;
Yuksek, Mutlu ;
Genel, Ferah ;
Kucukosmanoglu, Ercan ;
Baki, Ali ;
Bahceciler, Nerin N. ;
Rambhatla, Anupama ;
Nickerson, Derek W. ;
McGhee, Sean ;
Barlan, Isil B. ;
Chatila, Talal .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (02) :342-348
[2]   Regulation of IL-9 expression by IL-25 signaling [J].
Angkasekwinai, Pornpimon ;
Chang, Seon Hee ;
Thapa, Manoj ;
Watarai, Hiroshi ;
Dong, Chen .
NATURE IMMUNOLOGY, 2010, 11 (03) :250-U9
[3]  
Ashman RB, 2008, FRONT BIOSCI-LANDMRK, V13, P3334
[4]   Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans [J].
Bugarcic, Andrea ;
Hitchens, Kelly ;
Beckhouse, Anthony G. ;
Wells, Christine A. ;
Ashman, Robert B. ;
Blanchard, Helen .
GLYCOBIOLOGY, 2008, 18 (09) :679-685
[5]   An outline of the role of anti-Candida antibodies within the context of passive immunization and protection from candidiasis [J].
Cassone, A ;
De Bernardis, F ;
Torososantucci, A .
CURRENT MOLECULAR MEDICINE, 2005, 5 (04) :377-382
[6]   Anticandidal immunity and vaginitis: Novel opportunities for immune intervention [J].
Cassone, Antonio ;
De Bernardis, Flavia ;
Santoni, Giorgio .
INFECTION AND IMMUNITY, 2007, 75 (10) :4675-4686
[7]   T-HELPER CELL-TYPE-1 (TH1)-LIKE AND TH2-LIKE RESPONSES ARE PRESENT IN MICE WITH GASTRIC CANDIDIASIS BUT PROTECTIVE IMMUNITY IS ASSOCIATED WITH TH1 DEVELOPMENT [J].
CENCI, E ;
MENCACCI, A ;
SPACCAPELO, R ;
TONNETTI, L ;
MOSCI, P ;
ENSSLE, KH ;
PUCCETTI, P ;
ROMANI, L ;
BISTONI, F .
JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (05) :1279-1288
[8]   Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells [J].
Chen, Zhi ;
Laurence, Arian ;
Kanno, Yuka ;
Pacher-Zavisin, Margit ;
Zhu, Bing-Mei ;
Tato, Cristina ;
Yoshimura, Akihiko ;
Hennighausen, Lothar ;
O'Shea, John J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (21) :8137-8142
[9]   Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis [J].
Conti, Heather R. ;
Shen, Fang ;
Nayyar, Namrata ;
Stocum, Eileen ;
Sun, Jianing N. ;
Lindemann, Matthew J. ;
Ho, Allen W. ;
Hai, Justine Hoda ;
Yu, Jeffrey J. ;
Jung, Ji Won ;
Filler, Scott G. ;
Masso-Welch, Patricia ;
Edgerton, Mira ;
Gaffen, Sarah L. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (02) :299-311
[10]   Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells [J].
de Beaucoudrey, Ludovic ;
Puel, Anne ;
Filipe-Santos, Orchidee ;
Cobat, Aurelie ;
Ghandil, Pegah ;
Chrabieh, Maya ;
Feinberg, Jacqueline ;
von Bernuth, Horst ;
Samarina, Arina ;
Janniere, Lucile ;
Fieschi, Claire ;
Stephan, Jean-Louis ;
Boileau, Catherine ;
Lyonnet, Stanislas ;
Jondeau, Guillaume ;
Cormier-Daire, Valerie ;
Le Merrer, Martine ;
Hoarau, Cyrille ;
Lebranchu, Yvon ;
Lortholary, Olivier ;
Chandesris, Marie-Olivia ;
Tron, Francois ;
Gambineri, Eleonora ;
Bianchi, Lucia ;
Rodriguez-Gallego, Carlos ;
Zitnik, Simona E. ;
Vasconcelos, Julia ;
Guedes, Margarida ;
Vitor, Artur Bonito ;
Marodi, Laszlo ;
Chapel, Helen ;
Reid, Brenda ;
Roifman, Chaim ;
Nadal, David ;
Reichenbach, Janine ;
Caragol, Isabel ;
Garty, Ben-Zion ;
Dogu, Figen ;
Camcioglu, Yildiz ;
Gulle, Sanyie ;
Sanal, Ozden ;
Fischer, Alain ;
Abel, Laurent ;
Stockinger, Birgitta ;
Picard, Capucine ;
Casanova, Jean-Laurent .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1543-1550