High interindividual variability of methadone enantiomer blood levels to dose ratios

被引:48
作者
Eap, CB [1 ]
Bertschy, G [1 ]
Baumann, P [1 ]
Finkbeiner, T [1 ]
Gastpar, T [1 ]
Gastpar, M [1 ]
Scherbaum, N [1 ]
机构
[1] Univ Lausanne, Dept Psychiat Adulte, Unite Biochim & Psychopharmacol Clin, CH-1008 Lausanne, Switzerland
关键词
D O I
10.1001/archpsyc.55.1.89
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
引用
收藏
页码:89 / 90
页数:2
相关论文
共 10 条
[1]  
DAHL ML, 1995, J PHARMACOL EXP THER, V274, P516
[2]   Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone [J].
Eap, CB ;
Bertschy, G ;
Powell, K ;
Baumann, P .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1997, 17 (02) :113-117
[3]   Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: Interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics [J].
Eap, CB ;
Finkbeiner, T ;
Gastpar, M ;
Scherbaum, N ;
Powell, K ;
Baumann, P .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 50 (05) :385-389
[4]   THE INFLUENCE OF ENZYME-INDUCTION ON POLYMORPHIC SPARTEINE OXIDATION [J].
EICHELBAUM, M ;
MINESHITA, S ;
OHNHAUS, EE ;
ZEKORN, C .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 22 (01) :49-53
[5]   CAFFEINE AS A METABOLIC PROBE - EXPLORATION OF THE ENZYME-INDUCING EFFECT OF CIGARETTE-SMOKING [J].
KALOW, W ;
TANG, BK .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (01) :44-48
[6]   THE EMERGING ROLE OF CYTOCHROME-P450 3A IN PSYCHOPHARMACOLOGY [J].
KETTER, TA ;
FLOCKHART, DA ;
POST, RM ;
DENICOFF, K ;
PAZZAGLIA, PJ ;
MARANGELL, LB ;
GEORGE, MS ;
CALLAHAN, AM .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1995, 15 (06) :387-398
[7]  
KRISTENSEN K, 1995, LIFE SCI, V56, P45
[8]  
PAYTE JT, 1993, STATE METHADONE TREA, P101
[9]   EXPRESSION OF CYP1A1 AND CYP1A2 GENES IN HUMAN LIVER [J].
SCHWEIKL, H ;
TAYLOR, JA ;
KITAREEWAN, S ;
LINKO, P ;
NAGORNEY, D ;
GOLDSTEIN, JA .
PHARMACOGENETICS, 1993, 3 (05) :239-249
[10]  
WOLFF K, 1992, CLIN CHEM, V38, P438