IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

被引:103
作者
Waisman, Ari [1 ]
Kraus, Manfred
Seagal, Jane
Ghosh, Snigdha
Melamed, Doron
Song, Jian
Sasaki, Yoshiteru
Classen, Sabine
Lutz, Claudia
Brombacher, Frank
Nitschke, Lars
Rajewsky, Klaus
机构
[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany
[2] Univ Cologne, Ctr Mol Med, D-50674 Cologne, Germany
[3] Univ Mainz, Dept Med 1, D-55131 Mainz, Germany
[4] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[6] Univ Erlangen Nurnberg, Dept Genet, D-91058 Erlangen, Germany
[7] Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Immunol, IL-31096 Haifa, Israel
[8] Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
[9] Max Planck Inst Immunobiol, D-79011 Freiburg, Germany
[10] Univ Cape Town, Groote Schuur Hosp, Dept Immunol, ZA-7925 Cape Town, South Africa
关键词
D O I
10.1084/jem.20062024
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe a mouse strain in which B cell development relies either on the expression of membrane-bound immunoglobulin ( Ig) gamma 1 or mu heavy chains. Progenitor cells expressing gamma 1 chains from the beginning generate a peripheral B cell compartment of normal size with all subsets, but a partial block is seen at the pro- to pre-B cell transition. Accordingly, gamma 1-driven B cell development is disfavored in competition with developing B cells expressing a wild-type ( WT) IgH locus. However, the mutant B cells display a long half-life and accumulate in the mature B cell compartment, and even though partial truncation of the Ig alpha cytoplasmic tail compromises their development, it does not affect their maintenance, as it does in WT cells. IgG1-expressing B cells showed an enhanced Ca2+ response upon B cell receptor cross-linking, which was not due to a lack of inhibition by CD22. The enhanced Ca2+ response was also observed in mature B cells that had been switched from IgM to IgG1 expression in vivo. Collectively, these results suggest that the gamma 1 chain can exert a unique signaling function that can partially replace that of the Ig alpha/beta. heterodimer in B cell maintenance and may contribute to memory B cell physiology.
引用
收藏
页码:747 / 758
页数:12
相关论文
共 40 条
[1]   Effect of transmembrane and cytoplasmic domains of IgE on the IgE response [J].
Achatz, G ;
Nitschke, L ;
Lamers, MC .
SCIENCE, 1997, 276 (5311) :409-411
[2]   Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice [J].
Battegay, M ;
Fiedler, P ;
Kalinke, U ;
Brombacher, F ;
Zinkernagel, RM ;
Peter, HH ;
Kohler, G ;
Eibel, H .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (01) :250-258
[3]  
Bynoe MS, 1999, EUR J IMMUNOL, V29, P1304, DOI 10.1002/(SICI)1521-4141(199904)29:04<1304::AID-IMMU1304>3.0.CO
[4]  
2-6
[5]   A second heavy chain permits survival of high affinity autoreactive B cells [J].
Chu, YP ;
Spatz, L ;
Diamond, B .
AUTOIMMUNITY, 2004, 37 (01) :27-32
[6]   Models of signal transduction through the B-cell antigen receptor [J].
Geisberger, R ;
Crameri, R ;
Achatz, G .
IMMUNOLOGY, 2003, 110 (04) :401-410
[7]   Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow [J].
Hao, ZY ;
Rajewsky, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (08) :1151-1163
[8]   RESOLUTION AND CHARACTERIZATION OF PRO-B AND PRE-PRO-B CELL STAGES IN NORMAL MOUSE BONE-MARROW [J].
HARDY, RR ;
CARMACK, CE ;
SHINTON, SA ;
KEMP, JD ;
HAYAKAWA, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1213-1225
[9]   Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors [J].
Horikawa, Keisuke ;
Martin, Stephen W. ;
Pogue, Sarah L. ;
Silver, Karlee ;
Peng, Kaiman ;
Takatsu, Kiyoshi ;
Goodnow, Christopher C. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (04) :759-769
[10]  
ILIEV A, 1994, J IMMUNOL, V153, P3551