New targets and screening approaches in antimicrobial drug discovery

被引：156

作者：

Brown, ED ^{[1
]}

Wright, GD ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030116o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Filling the antimicrobial drug discovery pipeline is now more challenging than ever. The ever-mounting problem of resistance fuels the need for new agents. The stunning progress in 'omics'-scale research is now available to the antimicrobial community. Available screening methods and targets present the first pass at exploitation of new opportunities.

引用

页码：759 / 774

页数：16

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