A concise, biomimetic total synthesis of stephacidin A and notoamide B

被引：96

作者：

Greshock, Thomas J.

Grubbs, Alan W.

Tsukamoto, Sachiko

Williams, Robert M. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

[3] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 13期

关键词：

biomimetic synthesis; Diels-Alder reaction; indoles; metabolites; natural products;

D O I：

10.1002/anie.200604378

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Copying nature: A biomimetic total synthesis of stephacidin A has been accomplished using an intramolecular Diels-Alder reaction. Stephacidin A was then converted into notoamide B in a single step by oxaziridine-mediated oxidation to provide the first biomimetic total synthesis of notoamide B (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2262 / 2265

页数：4

共 47 条

[1]

[Anonymous], 2005, ANGEW CHEM INT EDIT, DOI DOI 10.1002/ANGE.200461864

[2] STUDIES IN RELATION TO BIOSYNTHESIS .46. INCORPORATION OF CYCLO-L-TRYPTOPHYL-L-PROLINE INTO BREVIANAMIDE A [J].