Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

被引：8

作者：

Liotta, LA

Medina, I

Robinson, JL

Carroll, CL

Pan, PS

Corral, R

Johnston, JVC

Cook, KM

Curtis, FA

Sharples, GJ

McAlpine, SR

机构：

[1] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA

[2] Univ Durham, Wolfson Res Inst, Ctr Infect Dis, Stockton On Tees TS17 6BH, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

macrocycles; peptides; antibiotics; Holliday junction; macrocyclic peptides; C-2; symmetrical;

D O I：

10.1016/j.tetlet.2004.09.084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8447 / 8450

页数：4

共 22 条

[1] Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein [J].