A novel RING finger protein, BFP, predominantly expressed in the brain

被引:11
作者
Inoue, S
Orimo, A
Saito, T
Ikeda, K
Sakata, K
Hosoi, T
Orimo, H
Ouchi, Y
Muramatsu, M
机构
[1] SAITAMA MED SCH,DEPT BIOCHEM,MOROYAMA,SAITAMA 35004,JAPAN
[2] UNIV TOKYO,FAC MED,DEPT GERIATR,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1006/bbrc.1997.7589
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RING finger is a variant zinc finger motif present in a new family of proteins including transcription regulators. A genomic DNA fragment containing RING finger motifs was identified by the polymerase chain reaction using degenerate primers. Using this fragment as a probe, we have isolated a novel cDNA from rat brain library. The predicted open reading frame contains a RING finger domain at its N-terminal portion. The corresponding transcript was detected predominantly in the brain and therefore was designated brain finger protein (bfp). An antibody raised against a recombinant bfp reveals the presence of the bfp in the brain. Interestingly, the bfp is induced during retinoic acid-mediated differentiation of P19 embryonal carcinoma cells into neural cells. These findings suggest the possible involvement of bfp in some aspects of neural cell regulation. (C) 1997 Academic Press.
引用
收藏
页码:8 / 14
页数:7
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