Growth of children at high risk of obesity during the first 6 y of life: implications for prevention

被引:58
作者
Berkowitz, RI
Stallings, VA
Maislin, G
Stunkard, AJ
机构
[1] Univ Penn, Weight & Eating Disorders Program, Dept Psychiat, Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat, Philadelphia, PA 19104 USA
[4] Childrens Hosp Philadelphia, Div GI & Nutr, Philadelphia, PA 19104 USA
[5] Biomed Stat Consulting, Wynnewood, PA USA
关键词
childhood; obesity; genetic influence; risk factors; body weight; fat mass; skinfold thickness;
D O I
10.1093/ajcn/81.1.140
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The contribution of familial factors to adiposity in children is poorly understood. Objective: The objective was to assess differences in growth in the first 6 y of life in children born to either overweight or lean mothers. Design: The body size and composition of 33 children at high risk and 37 children at low risk of obesity on the basis of the mother's overweight [body mass index (BMI; in kg /m(2)) of 30.2 +/- 4.2 and 19.5 +/- 1.1, respectively] were measured repeatedly from 3 mo to 6 y of age at the Children's Hospital of Philadelphia. Results: At year 2, no significant differences in any measure were observed between the high- and low-risk groups. By year 4, weight, BMI, and lean body mass were greater in the high-risk than in the low-risk children. By year 6, weight was even greater in the high-risk than in the low-risk children (23.4 +/- 6.4 compared with 20.4 +/- 2.1 kg; P < 0.02), and, for the first time, fat mass was greater in the high-risk than in the low-risk children (6.7 +/- 5.7 compared with 3.8 +/- 1.2 kg; P < 0.02). Ten of 33 high-risk children exceeded the 85th percentile of BMI at year 6 compared with I of 37 low-risk children (odds ratio = 15.7). Accelerated weight gain was predicted by high-risk group status, greater weight at year 2, and lower family income. Conclusion: Anthropometric measures were not significantly different between groups at year 2; weight and lean body mass were greater at years 4 and 6, and fat mass was greater at year 6 in high-risk children.
引用
收藏
页码:140 / 146
页数:7
相关论文
共 32 条
[1]   Obesity evaluation and treatment: Expert committee recommendations [J].
Barlow, SE ;
Dietz, WH .
PEDIATRICS, 1998, 102 (03)
[2]  
Brownell K., 2003, FOOD FIGHT
[3]  
CARDON JR, 1995, BEHAV GENETIC APPROA
[4]  
*CDCP, PUBL HLTH EP
[5]   DOES CHILDHOOD OBESITY TRACK INTO ADULTHOOD [J].
CLARKE, WR ;
LAUER, RM .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 1993, 33 (4-5) :423-430
[6]   The search for human obesity genes [J].
Comuzzie, AG ;
Allison, DB .
SCIENCE, 1998, 280 (5368) :1374-1377
[7]   RACE-SPECIFIC AND SEX-SPECIFIC REFERENCE DATA FOR TRICEPS AND SUBSCAPULAR SKINFOLDS AND WEIGHT STATURE [J].
CRONK, CE ;
ROCHE, AF .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1982, 35 (02) :347-354
[8]  
*CYT SOFTW CORP, 1998, STAT SOFTW EX NONP I
[9]  
FIGUEROACOLON R, 1995, J INVEST MED, V43, P43
[10]  
Garn S M, 1985, Curr Probl Pediatr, V15, P1