Enantioselective enzymatic desymmetrizations in organic synthesis

Enantioselective enzymatic desymmetrizations (EEDs) of meso and prochiral substrates have proved to be a powerful methodology that allows the preparation of a wide range of optically active building blocks in a highly enantioselective fashion and in high yields. Furthermore in most cases, enantiodivergence can be achieved by means of the employment of different enzymes, substrate engineering, or combination with other approaches such as kinetic resolutions (KRs) or metal catalysis. These factors make EEDs an attractive tool of asymmetric synthesis and convert them into an active field of research.