Protection against apoptosis by monoamine oxidase A inhibitors

被引:56
作者
Malorni, W
Giammarioli, AM
Matarrese, P
Pietrangeli, P
Agostinelli, E
Ciaccio, A
Grassilli, E
Mondovi, B
机构
[1] Ist Super Sanita, Dept Ultrastruct, I-00161 Rome, Italy
[2] Univ Rome La Sapienza, Dept Biochem Sci, Rome, Italy
[3] Univ Rome La Sapienza, CNR, Ctr Mol Biol, Rome, Italy
[4] Univ Modena, Dept Gen Pathol, Modena, Italy
关键词
apoptosis; mitochondrial membrane potential; amine oxidase;
D O I
10.1016/S0014-5793(98)00315-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:155 / 159
页数:5
相关论文
共 24 条
[1]   CYTOTOXICITY AND KINETIC-ANALYSIS OF PURIFIED BOVINE SERUM AMINE OXIDASE IN THE PRESENCE OF SPERMINE IN CHINESE-HAMSTER OVARY CELLS [J].
AVERILLBATES, DA ;
AGOSTINELLI, E ;
PRZYBYTKOWSKI, E ;
MATEESCU, MA ;
MONDOVI, B .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (01) :75-79
[2]  
Cesura A M, 1992, Prog Drug Res, V38, P171
[3]   A NEW METHOD FOR THE CYTOFLUOROMETRIC ANALYSIS OF MITOCHONDRIAL-MEMBRANE POTENTIAL USING THE J-AGGREGATE FORMING LIPOPHILIC CATION 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLCARBOCYANINE IODIDE (JC-1) [J].
COSSARIZZA, A ;
BACCARANICONTRI, M ;
KALASHNIKOVA, G ;
FRANCESCHI, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (01) :40-45
[4]   PROTECTIVE EFFECT OF N-ACETYLCYSTEINE IN TUMOR NECROSIS FACTOR-ALPHA-INDUCED APOPTOSIS IN U937 CELLS - THE ROLE OF MITOCHONDRIA [J].
COSSARIZZA, A ;
FRANCESCHI, C ;
MONTI, D ;
SALVIOLI, S ;
BELLESIA, E ;
RIVABENE, R ;
BIONDO, L ;
RAINALDI, G ;
TINARI, A ;
MALORNI, W .
EXPERIMENTAL CELL RESEARCH, 1995, 220 (01) :232-240
[5]   EVALUATION OF THE SIGNIFICANCE OF POLYAMINES AND THEIR OXIDASES IN THE ETIOLOGY OF HUMAN CERVICAL-CARCINOMA [J].
FERNANDEZ, C ;
SHARRARD, RM ;
TALBOT, M ;
REED, BD ;
MONKS, N .
BRITISH JOURNAL OF CANCER, 1995, 72 (05) :1194-1199
[6]   Apoptotic vs nonapoptotic cytotoxicity induced by hydrogen peroxide [J].
Gardner, AM ;
Xu, FH ;
Fady, C ;
Jacoby, FJ ;
Duffey, DC ;
Tu, YP ;
Lichtenstein, A .
FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (1-2) :73-83
[7]   DETERMINATION OF MONOAMINE-OXIDASE CONCENTRATIONS IN RAT-LIVER BY INHIBITOR BINDING [J].
GOMEZ, N ;
UNZETA, M ;
TIPTON, KF ;
ANDERSON, MC ;
OCARROLL, AM .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (24) :4467-4472
[8]   The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA [J].
Hauptmann, N ;
Grimsby, J ;
Shih, JC ;
Cadenas, E .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 335 (02) :295-304
[9]   Rapid induction of apoptosis by deregulated uptake of polyamine analogues [J].
Hu, RH ;
Pegg, AE .
BIOCHEMICAL JOURNAL, 1997, 328 :307-316
[10]   BCL-2 BLOCKS APOPTOSIS IN CELLS LACKING MITOCHONDRIAL-DNA [J].
JACOBSON, MD ;
BURNE, JF ;
KING, MP ;
MIYASHITA, T ;
REED, JC ;
RAFF, MC .
NATURE, 1993, 361 (6410) :365-369