Elisabethamine:: a new diterpene alkaloid from Pseudopterogorgia elisabethae

被引：17

作者：

Ata, A ^{[1
]}

Kerr, RG ^{[1
]}

机构：

[1] Florida Atlantic Univ, Dept Chem & Biochem, Ctr Mol Biol & Biotechnol, Boca Raton, FL 33431 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

alkaloids; anti-tumor compounds; anti-inflammatory compounds; NMR; mass spectrometry;

D O I：

10.1016/S0040-4039(00)00980-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Detailed chemical studies of the methanolic extract of Pseudopterogorgia elisabethae, collected from the Florida Keys, have resulted in the isolation of elisabethamine (1), a new diterpene alkaloid. Its structure was established with the aid of extensive spectroscopic studies. Compound 1 exhibited cytotoxicity against lung and prostate cancer cell lines as determined by an MITT assay. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5821 / 5825

页数：5

共 10 条

[1]

Ata A, 2000, HETEROCYCLES, V53, P717

[2]

CHANG CWJ, 1993, MARINE NATURAL PRODU, P33

[3] THE SECO-PSEUDOPTEROSINS, NEW ANTIINFLAMMATORY DITERPENE-GLYCOSIDES FROM A CARIBBEAN GORGONIAN OCTOCORAL OF THE GENUS PSEUDOPTEROGORGIA [J].

LOOK, SA ;

FENICAL, W .

TETRAHEDRON, 1987, 43 (15) :3363-3370

[4] THE PSEUDOPTEROSINS - A NEW CLASS OF ANTIINFLAMMATORY AND ANALGESIC DITERPENE PENTOSIDES FROM THE MARINE SEA WHIP PSEUDOPTEROGORGIA-ELISABETHAE (OCTOCORALLIA) [J].

LOOK, SA ;

FENICAL, W ;

MATSUMOTO, GK ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (26) :5140-5145

[5] Isolation and structure of aceropterine, a rare pseudopterane alkaloid from the Caribbean sea plume Pseudopterogorgia acerosa (Pallas). [J].

Rodriguez, AD ;

Soto, JJ .

TETRAHEDRON LETTERS, 1996, 37 (16) :2687-2690

[6] Unusual terpenes with novel carbon skeletons from the West Indian sea whip Pseudopterogorgia elisabethae (Octocorallia) [J].

Rodríguez, AD ;

González, E ;

Huang, SD .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (20) :7083-7091

[7] Novel antimycobacterial benzoxazole alkaloids, from the West Indian sea whip Pseudopterogorgia elisabethae [J].

Rodríguez, AD ;

Ramírez, C ;

Rodríguez, II ;

González, E .

ORGANIC LETTERS, 1999, 1 (03) :527-530

[8] THE NATURAL-PRODUCTS CHEMISTRY OF WEST-INDIAN GORGONIAN OCTOCORALS [J].

RODRIGUEZ, AD .

TETRAHEDRON, 1995, 51 (16) :4571-4618

[9] Elisabatins A and B:: New amphilectane-type diterpenes from the west Indian sea whip Pseudopterogorgia elisabethae [J].

Rodríguez, AD ;

Ramírez, C ;

Rodríguez, II .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (07) :997-999

[10] NEW ANTIINFLAMMATORY PSEUDOPTEROSINS FROM THE MARINE OCTOCORAL PSEUDOPTEROGORGIA-ELISABETHAE [J].

ROUSSIS, V ;

WU, ZD ;

FENICAL, W ;

STROBEL, SA ;

VANDUYNE, GD ;

CLARDY, J .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (16) :4916-4922

← 1 →