Primary endocervical extraosseous Ewing's sarcoma/PNET

被引:44
作者
Cenacchi, G
Pasquinelli, G
Montanaro, L
Cerasoli, S
Vici, M
Bisceglia, M
Giangaspero, F
Martinelli, GN
Derenzini, M
机构
[1] Univ Bologna, Dipartimento Patol Sperimentale, Sez Citopatol & Diagnost Ultrastrutturale, I-40138 Bologna, Italy
[2] Univ Bologna, Dipartimento Clin Sci Radiol & Istocitopatol, Sez Anat Istol & Citol Patol M Malpighi, I-40138 Bologna, Italy
[3] Osped di Cesena, Serv Anat Patol, S Giovanni Rotondo, Italy
关键词
uterine cervix; extraosseous ES/PNET; electron microscopy; immunohistochemistry; molecular pathology; RT-PCR;
D O I
10.1097/00004347-199801000-00015
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
A 36-year-old woman presented with intermenstrual spotting and was found to have a cystic mass involving the uterine cervix on a pelvic ultrasound examination. A necrotic and hemorragic tumor was excised by hysterectomy and processed for light and electron microscopic investigation and molecular analysis. Microscopic examination revealed a small round cell tumor that immunohistochemical studies (including staining for the highly restricted surface antigen p30/32(MIC2)) and ultrastructural studies indicated was an extraosseous Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET). This diagnosis was established by detection of EWS/ERG fusion transcript through reverse transcription polymerase chain reaction (RT-PCR) with nested primers. Full body computed tomography failed to detect any extrauterine tumor, and the patient is clinically free of disease 18 months after hysterectomy. This case represents the first report of a primary EES/PNET arising in the uterine cervix.
引用
收藏
页码:83 / 88
页数:6
相关论文
共 26 条
[1]   Detection of t(11;22)(q24;q12) translocation breakpoint in paraffin-embedded tissue of the Ewing's sarcoma family by nested reverse transcription-polymerase chain reaction [J].
Adams, V ;
Hany, MA ;
Schmid, M ;
Hassam, S ;
Briner, J ;
Niggli, FK .
DIAGNOSTIC MOLECULAR PATHOLOGY, 1996, 5 (02) :107-113
[2]   ESTABLISHMENT AND CHARACTERIZATION OF A PRIMITIVE NEUROECTODERMAL TUMOR OF BONE CONTINUOUS CELL-LINE (LAP-35) [J].
BAGNARA, GP ;
SERRA, M ;
GIOVANNINI, M ;
BADIALI, M ;
STELLA, M ;
MONTALDI, A ;
GRANCHI, D ;
PAOLUCCI, P ;
ROCCHI, P ;
PESSION, A ;
PICCI, P ;
PAOLUCCI, G ;
CAMPANACCI, M ;
TESSAROLLO, L ;
CAVAZZANA, AO .
INTERNATIONAL JOURNAL OF CELL CLONING, 1990, 8 (06) :409-424
[3]  
CAVAZZANA AO, 1992, MODERN PATHOL, V5, P71
[4]  
CLEMENT PB, 1990, SEMIN DIAGN PATHOL, V7, P228
[5]   PRIMITIVE NEUROECTODERMAL TUMORS OF THE UTERUS - A REPORT OF 4 CASES [J].
DAYA, D ;
LUKKA, H ;
CLEMENT, PB .
HUMAN PATHOLOGY, 1992, 23 (10) :1120-1129
[6]   PRIMITIVE NEUROECTODERMAL TUMOR AND EWINGS-SARCOMA [J].
DEHNER, LP .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1993, 17 (01) :1-13
[7]  
DEHNER LP, 1994, ARCH PATHOL LAB MED, V118, P606
[8]   THE EWING FAMILY OF TUMORS - A SUBGROUP OF SMALL-ROUND-CELL TUMORS DEFINED BY SPECIFIC CHIMERIC TRANSCRIPTS [J].
DELATTRE, O ;
ZUCMAN, J ;
MELOT, T ;
GARAU, XS ;
ZUCKER, JM ;
LENOIR, GM ;
AMBROS, PF ;
SHEER, D ;
TURCCAREL, C ;
TRICHE, TJ ;
AURIAS, A ;
THOMAS, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (05) :294-299
[9]   COMPARISON OF CELL-SURFACE ANTIGEN HBA71 (P30/32MIC2), NEURON-SPECIFIC ENOLASE, AND VIMENTIN IN THE IMMUNOHISTOCHEMICAL ANALYSIS OF EWINGS-SARCOMA OF BONE [J].
FELLINGER, EJ ;
GARINCHESA, P ;
GLASSER, DB ;
HUVOS, AG ;
RETTIG, WJ .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1992, 16 (08) :746-755
[10]   Large cell carcinoma of the uterine cervix: A clinicopathologic study of 12 cases [J].
Gilks, CB ;
Young, RH ;
Gersell, DJ ;
Clement, PB .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (08) :905-914