Total synthesis of epothilone A

被引：70

作者：

Zhu, B

Panek, JS

机构：

[1] Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Metcalf Ctr Sci & Engn, Ctr Streamlined Synth, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 17期

关键词：

D O I：

10.1021/ol006104w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Epothilones A (1) and B (2) are potent antitumor natural products with a Taxol like mechanism of action. A total synthesis of epothilone A (1) is reported, which utilized chiral silane based bond construction methodology to introduce the key C-6 and C-7 stereocenters of fragment 4. The C-15 stereocenter of fragment 5 was established by a lipase mediated kinetic resolution. The fragments were assembled with a Suzuki coupling reaction and an aldol condensation end cyclized with a Yamaguchi type macrolactonization reaction.

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页码：2575 / 2578

页数：4

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