Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA

被引：114

作者：

Wu, C

Kobayashi, H

Sun, B

Yoo, TM

Paik, CH

Gansow, OA

Carrasquillo, JA

Pastan, I

Brechbiel, MW

机构：

[1] NCI,RADIAT ONCOL BRANCH,RADIOIMMUNE & INORGAN CHEM SECT,NIH,BETHESDA,MD 20892

[2] NCI,DEPT NUCL MED,NIH,BETHESDA,MD 20892

[3] NCI,MOL BIOL LAB,NIH,BETHESDA,MD 20892

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1997年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(97)00130-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Distinct differences in in vivo stability of the two diastereomeric C-Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo. Published by Elsevier Science Ltd.

引用

页码：1925 / 1934

页数：10

共 27 条

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