Amylin receptors: molecular composition and pharmacology

被引：66

作者：

Hay, DL

Christopoulos, G

Christopoulos, A

Sexton, PM

机构：

[1] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand

[2] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

amylin; calcitonin receptor; receptor activity modifying protein 1 (RAMP1); RAMP2; RAMP3;

D O I：

10.1042/BST0320865

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT(a)) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.

引用

收藏

页码：865 / 867

页数：3

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