Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3

被引：105

作者：

Cheng, Y

Poulos, NE

Lung, ML

Hampton, G

Ou, BX

Lerman, MI

Stanbridge, EJ

机构：

[1] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

[2] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong

[3] Genos Biosci Inc, La Jolla, CA 92037 USA

[4] Sun Yatsen Univ Med Sci, Inst Canc, Guangzhou, Peoples R China

[5] NCI, Frederick, MD 21702 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 06期

关键词：

D O I：

10.1073/pnas.95.6.3042

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.

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页码：3042 / 3047

页数：6

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