Practical asymmetric synthesis of β-trichloromethyl-β-hydroxy ketones by the reaction of chloral or chloral hydrate with chiral imines

被引：9

作者：

Funabiki, K ^{[1
]}

Honma, N ^{[1
]}

Hashimoto, W ^{[1
]}

Matsui, M ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 12期

关键词：

D O I：

10.1021/ol034461b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chloral or its hydrate undergoes the carbon-carbon bond-formation reaction with various optically active imines in the absence of any additive, followed by hydrolysis, to produce the corresponding beta-trichloromethyl-beta-hydroxy ketones in good yields with high enantioselectivities. In addition, the products with higher ee values were obtained by a simple recrystallization process.

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页码：2059 / 2061

页数：3

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