Adherin: Key to the cohesin ring and Cornelia de Lange syndrome

被引：31

作者：

Dorsett, D ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 19期

关键词：

D O I：

10.1016/j.cub.2004.09.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adherin facilitates sister chromatid cohesion, DNA repair and binding of the cohesin complex to chromosomes. New studies indicate that adherin activity is coordinated with DNA replication and chromosome segregation, and that its dosage is critical for gene expression and human development.

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收藏

页码：R834 / R836

页数：3

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