Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists

被引：77

作者：

Hipskind, PA

Lobb, KL

Nixon, JA

Britton, TC

Bruns, RF

Catlow, J

DieckmanMcGinty, DK

Gackenheimer, SL

Gitter, BD

Iyengar, S

Schober, DA

Simmons, RMA

Swanson, S

Zarrinmayeh, H

Zimmerman, DM

Gehlert, DR

机构：

[1] Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 23期

关键词：

D O I：

10.1021/jm970512x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3712 / 3714

页数：3

共 17 条

[1] NEUROPEPTIDE-Y DISTRIBUTION IN THE RAT-BRAIN [J].

ALLEN, YS ;

ADRIAN, TE ;

ALLEN, JM ;

TATEMOTO, K ;

CROW, TJ ;

BLOOM, SR ;

POLAK, JM .

SCIENCE, 1983, 221 (4613) :877-879

[2] STRUCTURE-ACTIVITY-RELATIONSHIPS OF NEUROPEPTIDE-Y ANALOGS WITH RESPECT TO Y-1 AND Y-2 RECEPTORS [J].

BECKSICKINGER, AG ;

JUNG, G .

BIOPOLYMERS, 1995, 37 (02) :123-142

[3] NEUROPEPTIDE Y (NPY)-INDUCED FEEDING-BEHAVIOR IN FEMALE RATS - COMPARISON WITH HUMAN NPY ([MET17]NPY), NPY ANALOG ([NORLEU4]NPY) AND PEPTIDE-YY [J].

CLARK, JT ;

SAHU, A ;

KALRA, PS ;

BALASUBRAMANIAM, A ;

KALRA, SP .

REGULATORY PEPTIDES, 1987, 17 (01) :31-39

[4] NEUROPEPTIDE-Y AND HUMAN PANCREATIC-POLYPEPTIDE STIMULATE FEEDING-BEHAVIOR IN RATS [J].

CLARK, JT ;

KALRA, PS ;

CROWLEY, WR ;

KALRA, SP .

ENDOCRINOLOGY, 1984, 115 (01) :427-429

[5] NEUROPEPTIDE-Y MOBILIZES INTRACELLULAR CA2+ AND INCREASES INOSITOL PHOSPHATE PRODUCTION IN HUMAN ERYTHROLEUKEMIA-CELLS [J].

DANIELS, AJ ;

LAZAROWSKI, ER ;

MATTHEWS, JE ;

LAPETINA, EG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1138-1144

[6]

DOODS HN, 1995, J PHARMACOL EXP THER, V275, P136

[7] Treating obesity in the 21st century [J].

Gehlert, DR ;

Goldstein, DJ ;

Hipskind, PA .

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 31, 1996, 31 :201-210

[8]

GEHLERT DR, 1995, CURR PHARM DESIGN, V1, P295

[9]

Hipskind PA, 1996, ANNU REP MED CHEM, V31, P1

[10] CONTROL OF FEEDING AND SEXUAL BEHAVIORS BY NEUROPEPTIDE-Y - PHYSIOLOGICAL IMPLICATIONS [J].

KALRA, SP ;

CLARK, JT ;

SAHU, A ;

DUBE, MG ;

KALRA, PS .

SYNAPSE, 1988, 2 (03) :254-257

← 1 2 →