Anatomical and Functional Connectivity of Cytoarchitectonic Areas within the Human Parietal Operculum

被引:283
作者
Eickhoff, Simon B. [1 ,2 ,3 ]
Jbabdi, Saad [4 ]
Caspers, Svenja [1 ,3 ]
Laird, Angela R. [5 ]
Fox, Peter T. [5 ]
Zilles, Karl [1 ,3 ,6 ]
Behrens, Timothy E. J. [4 ,7 ]
机构
[1] Forschungszentrum Julich, Inst Neurosci & Med INM 2, D-52425 Julich, Germany
[2] Rhein Westfal TH Aachen Univ, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany
[3] Julich Aachen Res Alliance, Translat Brain Med, D-52425 Julich, Germany
[4] Univ Oxford, John Radcliffe Hosp, Oxford Ctr Funct MRI Brain, Oxford OX3 9D2, England
[5] Univ Texas Hlth Sci Inst, Res Imaging Ctr, San Antonio, TX 78229 USA
[6] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40225 Dusseldorf, Germany
[7] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
关键词
2ND SOMATOSENSORY AREA; POSITRON-EMISSION-TOMOGRAPHY; RECEPTIVE-FIELD PROPERTIES; LATERAL SULCUS; SOMATOTOPIC ORGANIZATION; INTERINDIVIDUAL VARIABILITY; CORTICAL CONNECTIONS; MACAQUE MONKEYS; STEREOTAXIC SPACE; ALE METAANALYSIS;
D O I
10.1523/JNEUROSCI.5664-09.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In monkeys, the somatosensory cortex on the parietal operculum can be differentiated into several distinct cortical fields. Potential human homologues for these areas have already been defined by cytoarchitectonic mapping and functional imaging experiments. Differences between the two most widely studied areas [operculum parietale (OP) 1 and OP 4] within this region particularly pertain to their connection with either the perceptive parietal network or the frontal motor areas. In the present study, we investigated differences in anatomical connection patterns probed by probabilistic tractography on diffusion tensor imaging data. Functional connectivity was then mapped by coordinate-based meta-analysis of imaging studies. Comparison between these two aspects of connectivity showed a good congruency and hence converging evidence for an involvement of these areas in matching brain networks. There were, however, also several instances in which anatomical and functional connectivity diverged, underlining the independence of these measures and the need for multimodal characterization of brain connectivity. The connectivity analyses performed showed that the two largest areas within the human parietal operculum region display considerable differences in their connectivity to frontoparietal brain regions. In particular, relative to OP 1, area OP 4 is more closely integrated with areas responsible for basic sensorimotor processing and action control, while OP 1 is more closely connected to the parietal networks for higher order somatosensory processing. These results are largely congruent with data on nonhuman primates. Differences between anatomical and functional connectivity as well as between species, however, highlight the need for an integrative view on connectivity, including comparison and cross-validation of results from different approaches.
引用
收藏
页码:6409 / 6421
页数:13
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