Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARα/γ agonists

被引：111

作者：

Godfrey, AG ^{[1
]}

Brooks, DA ^{[1
]}

Hay, LA ^{[1
]}

Peters, M ^{[1
]}

McCarthy, JR ^{[1
]}

Mitchell, D ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 07期

关键词：

D O I：

10.1021/jo026655v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.

引用

页码：2623 / 2632

页数：10

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