Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: Pathologic and molecular studies

被引：36

作者：

Mircescu, H

Parma, J

Huot, C

Deal, C

Oligny, LL

Vassart, G

Van Vliet, G

机构：

[1] Univ Montreal, Hop St Justine, Serv Endocrinol, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Free Univ Brussels, Inst Interdisciplinary Res, Brussels, Belgium

来源：

JOURNAL OF PEDIATRICS | 2000年 / 137卷 / 04期

关键词：

D O I：

10.1067/mpd.2000.108437

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia.

引用

页码：585 / 587

页数：3

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