Metoclopramide toxicity in an infant

被引:21
作者
Batts, KF [1 ]
Munter, DW [1 ]
机构
[1] USN, Med Ctr, Dept Emergency Med, Portsmouth, VA 23708 USA
关键词
metoclopramide; toxicity; overdose; adverse reactions;
D O I
10.1097/00006565-199802000-00011
中图分类号
R4 [临床医学];
学科分类号
1002 [临床医学]; 100602 [中西医结合临床];
摘要
Metoclopramide (4-amino-5-chloro-N-2-methoxybenzamide) is a central and peripheral acting dopamine antagonist. It also stimulates motility in the upper gastrointestinal tract and increases lower esophageal sphincter pressure. In the pediatric population, it is used extensively as an antiemetic and in the treatment of gastroesophageal reflux disease. The case of a six-month-old infant who was accidentally overdosed,vith 24 mg (3 mg/kg) of metoclopramide within a nine-hour period is presented. The patient demonstrated toxic extrapyramidal effects. There have been multiple early reports in the European literature of acute extrapyramidal reactions in the pediatric population, but no reports of toxicity exist in the current emergency medicine literature.
引用
收藏
页码:39 / 41
页数:3
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