The chemistry and biology of epothilones - The wheel keeps turning

被引：106

作者：

Altmann, Karl-Heinz

Pfeiffer, Bernhard

Arseniyadis, Stellios

Pratt, Benjamin A.

Nicolaou, K. C.

机构：

[1] ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences

[2] Department of Chemistry, Skaggs Institute for Chemical Biology, Scripps Research Institute, San Diego, CA 92037

[3] Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA 92093

来源：

CHEMMEDCHEM | 2007年 / 2卷 / 04期

关键词：

D O I：

10.1002/cmdc.200600206

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Epothilones have captured the attention of chemists, biologists, and drug researchers ever since they were found to inhibit human cancer cell growth through a "taxol-like" mechanism over ten years ago. Today, at least seven epothilone-derived agents have entered clinical trials. However, additional new and exciting analogues have emerged in recent years, suggesting that the potential of these natural products to serve as leads for new anticancer drugs is far from exhausted. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：396 / 423

页数：28

共 216 条

[1] Design, total synthesis, and evaluation of novel open-chain epothilone analogues [J].