The Kin I kinesins are microtubule end-stimulated ATPases

被引：29

作者：

Walczak, CE ^{[1
]}

机构：

[1] Indiana Univ, Bloomington, IN 47405 USA

来源：

MOLECULAR CELL | 2003年 / 11卷 / 02期

关键词：

D O I：

10.1016/S1097-2765(03)00067-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Kin I kinesins are microtubule-destabilizing enzymes important for neuronal transport, spindle assembly, and chromosome segregation. Hunter et al. (2003) now show that the Kin I MCAK is a microtubule end-stimulated ATPase that can catalytically depolymerize MT's.

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页码：286 / 288

页数：3

相关论文

共 8 条

[1]

CHANDRA R, 1993, J CELL SCI, V104, P899

[2] Microtubule polymerization dynamics [J].

Desai, A ;

Mitchison, TJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :83-117

[3] Kin I kinesins are microtubule-destabilizing enzymes [J].

Desai, A ;

Verma, S ;

Mitchison, TJ ;

Walczak, CE .

CELL, 1999, 96 (01) :69-78

[4] The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends [J].

Hunter, AW ;

Caplow, M ;

Coy, DL ;

Hancock, WO ;

Diez, S ;

Wordeman, L ;

Howard, J .

MOLECULAR CELL, 2003, 11 (02) :445-457

[5] Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin [J].

Maney, T ;

Wagenbach, M ;

Wordeman, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34753-34758

[6] A mechanism for microtubule depolymerization by KinI kinesins [J].

Moores, CA ;

Yu, M ;

Guo, J ;

Beraud, C ;

Sakowicz, R ;

Milligan, RA .

MOLECULAR CELL, 2002, 9 (04) :903-909

[7] XKCM1 acts on a single protofilament and requires the C terminus of tubulin [J].

Niederstrasser, H ;

Salehi-Had, H ;

Gan, EC ;

Walczak, C ;

Nogales, E .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (03) :817-828

[8] K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant [J].

Ovechkina, Y ;

Wagenbach, M ;

Wordeman, L .

JOURNAL OF CELL BIOLOGY, 2002, 159 (04) :557-562