Lipid droplets: A dynamic organelle moves into focus

被引：219

作者：

Beller, Mathias ^{[1
]}

Thiel, Katharina ^{[1
]}

Thul, Peter J. ^{[1
]}

Jaeckle, Herbert ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Abt Mol Entwicklungsbiol, D-37077 Gottingen, Germany

来源：

FEBS LETTERS | 2010年 / 584卷 / 11期

关键词：

Lipid droplet; Organelle interaction; Endoplasmic reticulum; Vesicles; SEIP CONGENITAL LIPODYSTROPHY; ADIPOSE TRIGLYCERIDE LIPASE; ENDOPLASMIC-RETICULUM; FAT STORAGE; PROTEIN; DROSOPHILA; PERILIPIN; MEMBRANE; REVEALS; BODIES;

D O I：

10.1016/j.febslet.2010.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in the energy homeostasis of both cells and entire organisms. However, this view has changed recently after the realization of a complex and highly dynamic LD proteome. The proteome contains key components of the fat mobilization system and proteins that suggest LD interactions with a variety of cell organelles, including the endoplasmic reticulum, mitochondria and peroxisomes. The study of LD cell biology, including cross-talk with other organelles, the trafficking of LDs in the cell and regulatory events involving the LD coat proteins is now on the verge of leaving its infancy and unfolds that LDs are highly dynamic cellular organelles. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2176 / 2182

页数：7

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