A facile solution phase combinatorial synthesis of tetrasubstituted pyridines using the Bohlmann-Rahtz heteroannulation reaction

被引：37

作者：

Bagley, MC

Dale, JW

Ohnesorge, M

Xiong, X

Bower, J

机构：

[1] Univ Wales Coll Cardiff, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

[2] RiboTargets Ltd, Cambridge CB1 6GB, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2003年 / 5卷 / 01期

关键词：

SOLID-PHASE; PROMOTHIOCIN-A; HETEROCYCLES; PYRIDO<2,3-D>PYRIMIDINES; KETONES;

D O I：

10.1021/cc020067d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The solution phase combinatorial Bohlmann-Rahtz reaction gives highly functionalized pyridine libraries from enamino esters and alkynones in a single synthetic step. Good product ratios and library purities were obtained in reactions catalyzed by zinc(II) bromide, the acid-catalyzed heteroannulation procedure offering considerable improvements over traditional methodology.

引用

页码：41 / 44

页数：4

共 19 条

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