The direct catalytic asymmetric cross-aldol reaction of aldehydes

被引:127
作者
Alcaide, B [1 ]
Almendros, P
机构
[1] Univ Complutense Madrid, Fac Quim, Dept Quim Organ 1, E-28040 Madrid, Spain
[2] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
关键词
aldol reactions; asymmetric catalysis; asymmetric synthesis; C-C coupling; enantioselectivity;
D O I
10.1002/anie.200390232
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Although the more elegant and most economically attractive way to introduce chirality into a molecule is by using a catalytic amount of chiral controller to induce chiral transformation without the need for any other activation of the starting materials, the first report of chemical catalysis for the direct catalytic asymmetric cross-aldol reaction of aldehydes has only recently appeared (see scheme).
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页码:858 / 860
页数:3
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