6-hydroxydiscodermindole, a new discodermindole from the marine sponge Discodermia polydiscus

被引：17

作者：

Cohen, J ^{[1
]}

Paul, GK ^{[1
]}

Gunasekera, SP ^{[1
]}

Longley, RE ^{[1
]}

Pomponi, SA ^{[1
]}

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

来源：

PHARMACEUTICAL BIOLOGY | 2004年 / 42卷 / 01期

关键词：

cytotoxicity; Discodermia polydiscus de Bocage; porifera; demospongia; lithistida; marine sponge; NMR data; 6-hydroxydiscodermindole;

D O I：

10.1080/13880200490505546

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

6-Hydroxydiscodermindole (2), a new discodermindole analogue, has been isolated from the deep-water marine sponge Discodermia polydiscus. It showed marginal in vitro cytotoxicity against cultured murine P388 leukemia cells. The isolation, structure elucidation and cytotoxicity of 6-hydroxydiscodermindole (2) is described.

引用

页码：59 / 61

页数：3