Baicalin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells

被引：9

作者：

Yang, Guang ^{[1
]}

Li, Jian-Qiang ^{[1
]}

Bo, Jian-Ping ^{[1
]}

Wang, Bei ^{[1
]}

Tian, Xin-Rui ^{[1
]}

Liu, Tan-Zhen ^{[1
]}

Liu, Zhuo-La ^{[1
]}

机构：

[1] Shanxi Med Univ, Hosp 2, Dept Resp & Crit Care Med, 382 Wuyi Rd, Taiyuan 030001, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 11期

关键词：

Baicalin; rat airway smooth muscle (RASM) cell; proliferation; migration; IN-VITRO; TGF-BETA; EXPRESSION; ASTHMA; INJURY; APOPTOSIS; PATHWAYS; KINASES; MODEL; MICE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Airway smooth muscle (ASM) cell proliferation and migration play important roles in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell proliferation and migration. Baicalin is one of flavonoid extracts from Scutellaria baicalensis, which has an anti-asthma effect. However, little is known about its role in PDGF-induced proliferation and migration in rat ASM (RASM) cells. In this study, we aimed to investigate the effects of baicalin on PDGF-induced RASM cell proliferation and migration. We also identified the signaling pathway by which baicalin influences RASM cell proliferation and migration. In the current study, we demonstrated that baicalin suppressed PDGF-induced RASM cell proliferation, arrested PDGF-induced cell-cycle progression. It also suppressed PDGF-induced RASM cell migration. Furthermore, baicalin suppressed PDGF-induced expression of phosphorylated p38, ERK1/2 and JNK in RASM cells. In summary, our study is the first to show that baicalin pretreatment can significantly inhibit PDGF-induced RASM cell proliferation and migration by suppressing the MAPK signaling pathway, and baicalin may be a useful chemotherapeutic agent for asthma.

引用

页码：20532 / 20539

页数：8

共 30 条

[1]

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