Cell Migration Driven by Cooperative Substrate Deformation Patterns

被引：224

作者：

Angelini, Thomas E. ^{[1
]}

Hannezo, Edouard ^{[2
]}

Trepat, Xavier ^{[3
,4
]}

Fredberg, Jeffrey J. ^{[5
]}

Weitz, David A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[2] Ecole Normale Super, Dept Phys, F-75005 Paris, France

[3] Univ Barcelona, Inst Bioengn Catalunya, Barcelona 08036, Spain

[4] Ciber Enfermedades Resp, Barcelona 08036, Spain

[5] Harvard Univ, Program Mol & Integrat Physiol Sci, Sch Publ Hlth, Boston, MA 02115 USA

来源：

PHYSICAL REVIEW LETTERS | 2010年 / 104卷 / 16期

基金：

美国国家科学基金会;

关键词：

MOVEMENT; MORPHOGENESIS; STIFFNESS; FORCES; FLOCKS;

D O I：

10.1103/PhysRevLett.104.168104

中图分类号：

O4 [物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.

引用

页数：4

共 28 条

[1]

Swirling motion in a system of vibrated elongated particles [J].

Aranson, Igor S. ;

Volfson, Dmitri ;

Tsimring, Lev S. .

PHYSICAL REVIEW E, 2007, 75 (05)

[2]

Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions [J].

Beningo, KA ;

Lo, CM ;

Wang, YL .

METHODS IN CELL-MATRIX ADHESION, 2002, 69 :325-339

[3]

Traction fields, moments, and strain energy that cells exert on their surroundings [J].

Butler, JP ;

Tolic-Norrelykke, IM ;

Fabry, B ;

Fredberg, JJ .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 282 (03) :C595-C605

[4]

Stresses at the cell-to-substrate interface during locomotion of fibroblasts [J].

Dembo, M ;

Wang, YL .

BIOPHYSICAL JOURNAL, 1999, 76 (04) :2307-2316

[5]

OPTIMAL ESTIMATION OF CELL-MOVEMENT INDEXES FROM THE STATISTICAL-ANALYSIS OF CELL TRACKING DATA [J].

DICKINSON, RB ;

TRANQUILLO, RT .

AICHE JOURNAL, 1993, 39 (12) :1995-2010

[6]

Tissue cells feel and respond to the stiffness of their substrate [J].

Discher, DE ;

Janmey, P ;

Wang, YL .

SCIENCE, 2005, 310 (5751) :1139-1143

[7]

Dormann D, 2001, DEVELOPMENT, V128, P4535

[8]

Dunn G A, 1983, Agents Actions Suppl, V12, P14

[9]

Substrate compliance versus ligand density in cell on gel responses [J].

Engler, A ;

Bacakova, L ;

Newman, C ;

Hategan, A ;

Griffin, M ;

Discher, D .

BIOPHYSICAL JOURNAL, 2004, 86 (01) :617-628

[10]

Collective cell migration in morphogenesis and cancer [J].

Friedl, P ;

Hegerfeldt, Y ;

Tusch, M .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2004, 48 (5-6) :441-449

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