Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

被引：815

作者：

Cypess, Aaron M. ^{[1
]}

Weiner, Lauren S. ^{[1
]}

Roberts-Toler, Carla ^{[1
]}

Elia, Elisa Franquet ^{[2
]}

Kessler, Skyler H. ^{[1
]}

Kahn, Peter A. ^{[3
]}

English, Jeffrey ^{[2
]}

Chatman, Kelly ^{[4
]}

Trauger, Sunia A. ^{[4
]}

Doria, Alessandro ^{[5
]}

Kolodny, Gerald M. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Sect Integrat Physiol & Metab, Res Div,Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Div Nucl Med & Mol Imaging, Dept Radiol,Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] Albert Einstein Coll Med, Bronx, NY 10461 USA

[4] Harvard Univ, Small Mol Mass Spectrometry Facil, FAS Div Sci, Cambridge, MA 02138 USA

[5] Harvard Univ, Sch Med, Sect Genet & Epidemiol, Res Div,Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

CELL METABOLISM | 2015年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SELECTIVE BETA(3)-ADRENOCEPTOR AGONIST; ADULT HUMANS; ADRENOCEPTOR AGONIST; ENERGY-EXPENDITURE; COLD-EXPOSURE; DOUBLE-BLIND; FAT; THERMOGENESIS; METABOLISM; MIRABEGRON;

D O I：

10.1016/j.cmet.2014.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of beta 3-adrenergic receptor (AR) agonists stimulates rodent BAT, but this activity has never been demonstrated in humans. Here we determined the ability of 200 mg oral mirabegron (Myrbetriq, Astellas Pharma, Inc.), a beta 3-AR agonist currently approved to treat overactive bladder, to stimulate BAT as compared to placebo. Mirabegron led to higher BAT metabolic activity as measured via F-18-fluorodeoxyglucose (F-18-FDG) using positron emission tomography (PET) combined with computed tomography (CT) in all twelve healthy male subjects (p = 0.001), and it increased resting metabolic rate (RMR) by 203 +/- 40 kcal/day (+ 13%; p = 0.001). BAT metabolic activity was also a significant predictor of the changes in RMR (p = 0.006). Therefore, a beta 3-AR agonist can stimulate human BAT thermogenesis and may be a promising treatment for metabolic disease.

引用

页码：33 / 38

页数：6

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