A rotaxane-like complex with controlled-release characteristics

被引：51

作者：

Chiu, SH ^{[1
]}

Rowan, SJ ^{[1
]}

Cantrill, SJ ^{[1
]}

Glink, PT ^{[1
]}

Garrell, RL ^{[1
]}

Stoddart, JF ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006525d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A rotaxane-like complex, based on a dumbbell-shaped component containing an NH2+ recognition site for a [25]crown-8 ring component and a slippage stopper in the form of a p(tert-butyl)phenyl group, has been synthesized by a "threading-followed-by-stoppering" approach. The half-life for dissociation of this complex, which is very sensitive to its environment, can be varied from minutes to months by changing the temperature and the polarity of the solvent.

引用

页码：3631 / 3634

页数：4

共 33 条

[1] AGAM G, 1976, J AM CHEM SOC, V98, P5206, DOI 10.1021/ja00433a026
[2] Interlocked and intertwined structures and superstructures
Amabilino, DB
Stoddart, JF
[J]. CHEMICAL REVIEWS, 1995, 95 (08) : 2725 - 2828
[3] AMABILINO DB, 1999, MOL CATENANES ROTAXA
[4] [Anonymous], STIMUL CONCEPTS CHEM
[5] [Anonymous], 1997, CONTROLLED DRUG DELI
[6] The slipping approach to self-assembling [n]rotaxanes
Asakawa, M
Ashton, PR
Ballardini, R
Balzani, V
Belohradsky, M
Gandolfi, MT
Kocian, O
Prodi, L
Raymo, FM
Stoddart, JF
Venturi, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (02) : 302 - 310
[7] A new slippage synthesis
Ashton, PR
Fyfe, MCT
Schiavo, C
Stoddart, JF
White, AJP
Williams, DJ
[J]. TETRAHEDRON LETTERS, 1998, 39 (31) : 5455 - 5458
[8] SLIPPAGE - AN ALTERNATIVE METHOD FOR ASSEMBLING [2]ROTAXANES
ASHTON, PR
BELOHRADSKY, M
PHILP, D
STODDART, JF
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (16) : 1269 - 1274
[9] Rotaxane or pseudorotaxane? That is the question!
Ashton, PR
Baxter, I
Fyfe, MCT
Raymo, FM
Spencer, N
Stoddart, JF
White, AJP
Williams, DJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (10) : 2297 - 2307
[10] Self-assembly, spectroscopic, and electrochemical properties of [n]rotaxanes
Ashton, PR
Ballardini, R
Balzani, V
Belohradsky, M
Gandolfi, MT
Philp, D
Prodi, L
Raymo, FM
Reddington, MV
Spencer, N
Stoddart, JF
Venturi, M
Williams, DJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (21) : 4931 - 4951

← 1 2 3 4 →