Global analysis of dauer gene expression in Caenorhabditis elegans

被引:224
作者
Wang, J
Kim, SK [1 ]
机构
[1] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
来源
DEVELOPMENT | 2003年 / 130卷 / 08期
关键词
dauer; microarray; timecourse; C; elegans;
D O I
10.1242/dev.00363
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The dauer is a developmental stage in C. elegans that exhibits increased longevity, stress resistance, nictation and altered metabolism compared with normal worms. We have used DNA microarrays to profile gene expression differences during the transition from the dauer state to the non-dauer state and after feeding of starved L1 animals, and have identified 1984 genes that show significant expression changes. This analysis includes genes that encode transcription factors and components of signaling pathways that could regulate the entry to and exit from the dauer state, and genes that encode components of metabolic pathways important for dauer survival and longevity. Homologs of C elegans dauer-enriched genes may be involved in the disease process in parasitic nematodes.
引用
收藏
页码:1621 / 1634
页数:14
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