Emerging roles of MUC4 in cancer: A novel target for diagnosis and therapy

被引：120

作者：

Singh, Ajay P. ^{[1
]}

Chaturvedi, PaHavi ^{[1
]}

Batra, Surinder K. ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Biochem & Mol Biol, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 02期

关键词：

D O I：

10.1158/0008-5472.CAN-06-3114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.

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收藏

页码：433 / 436

页数：4

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