Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic

被引：43

作者：

Beloglazova, NG ^{[1
]}

Sil'nikov, VN ^{[1
]}

Zenkova, MA ^{[1
]}

Vlassov, VV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Bioorgan Chem, Novosibirsk 630090, Russia

来源：

FEBS LETTERS | 2000年 / 481卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

antisense oligonucleotide; ribonuclease mimic; tRNA; RNA cleavage;

D O I：

10.1016/S0014-5793(00)02029-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNA(Phe) at a single site adjacent to the target complementary sequence. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：277 / 280

页数：4

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