GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

被引：68

作者：

Raaschou-Nielsen, Ole

Sorensen, Mette

Hansen, Rikke D.

Frederiksen, Kirsten

Tjonneland, Anne

Overvad, Kim

Vogel, Ulla

机构：

[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen O, Denmark

[2] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[3] Natl Inst Occupat Hlth, Copenhagen, Denmark

来源：

CANCER LETTERS | 2007年 / 247卷 / 02期

关键词：

GPX1; polymorphism; smoking; alcohol; lung cancer;

D O I：

10.1016/j.canlet.2006.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：293 / 300

页数：8

共 41 条

[1] Effect of moderate alcohol intake on lipid peroxidation in plasma, erythrocyte and leukocyte and on some antioxidant enzymes [J].