Correlation of elevated plasma levels of two structurally related growth factors, heparin affin regulatory peptide and midkine, in advanced solid tumor patients

被引：17

作者：

Soulié, P

Héroult, M

Bernard-Pierrot, I

Caruelle, D

Oglobine, J

Barritault, D

Courty, J ^{[1
]}

机构：

[1] Univ Paris 12, CNRS, FRE 2412,CRRET, Lab Rech Croissance Regenerat & Reparat Tissulair, Creteil, France

[2] Ctr Rene Huguenin, St Cloud, France

来源：

CANCER DETECTION AND PREVENTION | 2004年 / 28卷 / 05期

关键词：

HARP; midkine; pleiotrophin; plasma; solid tumors; angiogenesis; anticancer treatment;

D O I：

10.1016/j.cdp.2004.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heparin affin regulatory peptide (HARP) and midkine (MK) are growth factors, expressed in carcinomas, neuroblastomas and gliomas. In this study, we measured the levels of HARP and MK in plasma samples from 77 cancer patients. The patients had advanced tumors with loco-regional (n = 18) or metastatic (n = 49) diseases and 10 patients have their diseases limited to the primary site. HARP and MK plasma concentrations were significantly higher in all of these different subgroups of cancer patients (P < 0.05 in all cases), when compared to healthy controls (n = 30). Neither HARP nor MK levels were significantly different between patients with loco-regional and metastatic tumors (P = 0.203 and 0.242, respectively). Moreover, a strong correlation between the elevations of the plasma levels of these two proteins (r(2) = 0.546) in these cancer patients was found. Measurements of these secreted angiogenic growth factors may be useful for evaluation of cancer diagnosis. (C) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.

引用

页码：319 / 324

页数：6

共 31 条

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