Recombination proteins in yeast

被引：593

作者：

Krogh, BO ^{[1
]}

Symington, LS ^{[1
]}

机构：

[1] Columbia Univ, Ctr Med, New York, NY 10032 USA

来源：

ANNUAL REVIEW OF GENETICS | 2004年 / 38卷

关键词：

double-strand break repair; RAD52 epistasis group; Holliday junction resolution; replication fork collapse;

D O I：

10.1146/annurev.genet.38.072902.091500

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae. The Rad52 group proteins are highly conserved among eukaryotes. Recent studies showing defects in homologous recombination and double-strand break repair in several human cancer-prone syndromes have emphasized the importance of this repair pathway in maintaining genome integrity. Herein, we review recent genetic, biochemical, and structural analyses of the genes and proteins involved in recombination.

引用

页码：233 / 271

页数：39

共 238 条

[1] SEMIDOMINANT SUPPRESSORS OF SRS2 HELICASE MUTATIONS OF SACCHAROMYCES-CEREVISIAE MAP IN THE RAD51 GENE, WHOSE SEQUENCE PREDICTS A PROTEIN WITH SIMILARITIES TO PROKARYOTIC RECA PROTEINS [J].