Catalytic enantioselective Strecker reaction of ketoimines

被引：227

作者：

Masumoto, S

Usuda, H

Suzuki, M

Kanai, M

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy, CREST, Tokyo, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 19期

关键词：

D O I：

10.1021/ja034980+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the catalytic enantioselective Strecker reaction (cyanation) of N-diphenylphosphinoyl ketoimines is described. The asymmetric catalyst is a chiral gadolinium complex prepared from Gd(OiPr)3 and the d-glucose-derived ligand 3 in a 1:2 ratio. The reaction has a broad substrate generality, giving high enantioselectivity from aromatic, ethyl, primary alkyl, and α,β-unsaturated ketoimines. The products could be easily converted to disubstituted α-amino acids and their derivatives. Copyright © 2003 American Chemical Society.

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页码：5634 / 5635

页数：2

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