Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

被引：129

作者：

Feris, Kevin ^{[2
]}

Otto, Caitlin ^{[2
]}

Tinker, Juliette ^{[2
]}

Wingett, Denise ^{[2
]}

Punnoose, Alex ^{[3
]}

Thurber, Aaron ^{[3
]}

Kongara, Madhu ^{[3
]}

Sabetian, Maryam ^{[3
]}

Quinn, Bonnie ^{[1
]}

Hanna, Charles ^{[3
]}

Pink, David ^{[1
]}

机构：

[1] St Francis Xavier Univ, Dept Phys, Antigonish, NS B2G 2W5, Canada

[2] Boise State Univ, Dept Biol, Boise, ID 83725 USA

[3] Boise State Univ, Dept Phys, Boise, ID 83725 USA

来源：

LANGMUIR | 2010年 / 26卷 / 06期

基金：

美国国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

OXIDE NANOPARTICLES; ESCHERICHIA-COLI; MONTE-CARLO; ZINC-OXIDE; OXIDATIVE STRESS; A-BAND; CYTOTOXICITY; CELLS; TIO2; LIPOPOLYSACCHARIDE;

D O I：

10.1021/la903491z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction oil nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We Conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.

引用

页码：4429 / 4436

页数：8

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