Azaphilone pigments from a yellow mutant of the fungus Monascus kaoliang

被引：112

作者：

Jongrungruangchok, S

Kittakoop, P

Yonsmith, B

Bavovada, R

Tanasupawat, S

Lartpornmatulee, N

Thebtaranonth, Y

机构：

[1] NSTDA, BIOTEC, Klongluang 12120, Pathumthani, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok 10330, Thailand

[3] Kasetsart Univ, Fac Sci, Dept Microbiol, Bangkok, Thailand

[4] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmaceut Bot, Bangkok 10330, Thailand

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 18期

关键词：

Monascus kaoliang; azaphilone pigments; monascusone A; monascusone B; food colorant;

D O I：

10.1016/j.phytochem.2004.08.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Azaphilone pigments, monascusones A (1) and B (2), together with two known azaphilones, monascin (3) and FK17-P2b2 (4), were isolated from the CH2Cl2 extract of a yellow mutant of the fungus M. kaoliang grown on rice. Structures of the isolated compounds were elucidated by analyses of spectroscopic data. Monascusone A (1), the major metabolite of M. kaoliang, showed no antimalarial (against Plasmodium falciparum), antitubercular (against Mycobacterium tuberculosis H37Ra), and antifungal (toward Candida albicans) activities. Compound I exhibited no cytotoxicity against BC (breast cancer) and KB (human epidermoid carcinoma of cavity) cell lines. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2569 / 2575

页数：7

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